Infection inhibition by the recombinant GBV-B E2e

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Table of contents

Acknowledgements
Table of Contents
List of abbreviations
General Introduction
Virus Entry
The role of viral envelope proteins in virus entry
Virus interaction with cell surface molecules
Principles of viral membrane fusion
Mechanisms to trigger viral membrane fusion
Structures of viral fusionproteins
The role of viral envelope proteins in immune evasion
Chapter.I Hepaciviruses and their entry to target cells
Introduction
Hepatitis C Virus
HCV pathogenesis
Animal models for HCV
GBVGB as a surrogate model for HCV
Genome organization of Hepaciviruses
Structural proteins
Non Gstructural proteins
HCV genotypes
Current treatment options
Experimental systems for studying HCV and GBVGB entry in vitro
Infectious cycle of HCV and GBVGB
Role of neutralizing antibodies in HCV infection
HCV immune escape strategies
3D structures of the main neutralizing epitopes
The rapeutic potential of neutralizing antibodies
Immune responses to GBVGB virus
Structural Characterization of the GB virus B Envelope Glycoprotein.E2
Background
Objectives
Results
Discussion!
Materials and methods
Background
Objective
Results
Discussion!
Materials and Methods
Chapter.II Baculovirus Envelope Protein F
Introduction
Baculoviridae family
Replication cycle
Baculovirus envelope fusion proteins
Characteristics of baculovirus F protein
The structural similarity between baculovirus F and paramyxovirus F proteins
Receptor Gbinding function of baculovirus F
Relationship between insect retroviruses and baculoviruses
Cellular orthologs of baculovirus F protein
Structural characterization of a baculovirus fusion protein ectodomain
Background
Objectives
Results
Discussion
Materials and Methods
Final.Discussion
Supplementary
Materials and Methods
References
Appendix
Crystallography techniques and terms used in the thesis
Table.of.Figures
Table.of.Tables