Anatomy of the striatal mosaic: multiple levels of organization at the core of the brain

Get Complete Project Material File(s) Now! » The striatum and its position in the basal ganglia loop The striatum is a large nucleus of the forebrain and the main input station of basal ganglia. Basal ganglia are a set of...

Decomposition of low molecular weight DNICs with thiolate ligand

Get Complete Project Material File(s) Now! » Microchip liquid chromatography Conventional chromatographic separation (LC) is the main separation method used due to its outstanding separation power and versatility [337]. Untill now it is less used than CE for on chip...

The maintenance of epithelium homeostasis in the adult small intestine

Get Complete Project Material File(s) Now! » The maintenance of epithelium homeostasis in the adult small intestine Homeostasis of the intestinal epithelium is ensured by the continuous cells division in the crypt and apoptosis both in the crypt and at...

Inclusion body myopathy associated with Paget’s disease of bone and frontotemporal dementia (IBMPFD)

Get Complete Project Material File(s) Now! » RNA-binding proteins aggregates are a hallmark of ALS and IBMPFD Similar to other neurodegenerative diseases, the degenerating neurons of ALS patients are characterized by the accumulation of protein aggregates (Forman et al., 2004)....

VIRAL VECTORS FOR GENE THERAPY OF OCULAR DISEASES

Get Complete Project Material File(s) Now! » Rhodopsin DNA sequence correction DNA repair by Homologous Recombination (HR) To date a lot of strategies are used to silence or modify the expression of a target gene, but those that are developed...

Challenges of detecting remote protein homology

Get Complete Project Material File(s) Now! » Proteins This chapter introduces some basic concepts about proteins that are objects of this study. In section 2.1, we discuss the importance of proteins for living organisms, and present some concepts about their...

ASSESSING POPULATION SIZE IN NOCTURNAL DWELLING SEABIRDS ACCOUNTING FOR DETECTION PROBABILITY AND HABITAT PREFERENCES: A SEQUENTIAL APPROACH

Get Complete Project Material File(s) Now! » The evidence-based conservation Whichever position is taken regarding big or small debates, conservation (like any other discipline) needs evidence whenever possible to prove if a management action gave the expected outcome or not...

Immune system and tumors: a complex discourse

Get Complete Project Material File(s) Now! » Cell to cell contact dependent suppression: Involvement of co-stimulatory and co-inhibitory signals The antigen recognition by T cells is initiated through the TCR engagement but its amplitude is regulated by the balance between...

Ion and neutron irradiation effects in SiC and SiC fibers

Get Complete Project Material File(s) Now! » SiC, SiC fibers and SiCf/SiCm composites SiC physico-chemical properties are interesting for nuclear applications. How-ever, its use as structural material is limited by its brittle nature, typical of ceramic materials. SiC-based composites, SiCf/SiCm,...

Regulation of adult hippocampal neurogenesis by GR in newborn neurons

Get Complete Project Material File(s) Now! » Stress and neurogenesis in the mammalian central nervous system The stress response in the brain The body strives to maintain homeostasis, or optimal biological functioning1–3. In order to achieve this, it needs to...