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Table of contents
Abbreviations
Table of Illustrations
Summary
Résumé
I. Introduction
1. Cilium: Structure and Signaling
1.1. Structure
1.1.1. Motile Cilia and Flagella
1.1.2. Primary Cilia
1.1.3. Ciliogenesis and Ciliary Subdomains
1.1.4. Intraflagellar Transport Mechanism
1.2. Ciliary Signaling
1.2.1. Hedgehog Signaling
1.2.2. PDGF Pathway
1.2.3. Wnt Pathway
1.2.4. Calcium Signaling
1.2.5. Fluid flow and Fluid Shear Stress
2. Autophagy
2.1. Role of Autophagy
2.2. Different Types of Autophagy
2.2.1. Macroautophagy
2.2.2. Chaperone-mediated Autophagy
2.2.3. Microautophagy
2.3. Autophagosome Machinery and Biogenesis
2.3.1. Initiation
2.3.2. Elongation
2.3.3. Maturation
2.3.4. The origin of the Autophagosome
2.4. Regulation of Autophagy
2.4.1. Diverse Regulatory Pathways
2.4.2. Post-translational Modifications of Autophagic Machinery
2.4.3. Transcriptional and Epigenetic Regulations of Autophagy
2.5. Physiological Role of Autophagy
2.5.1. Selective Autophagy
2.5.2. Autophagy during pre- and post-natal state
2.5.3. Autophagy in the liver
2.5.4. Autophagy in the brain
2.5.5. Autophagy in the muscle
2.5.6. Autophagy in the intestine
2.5.7. Autophagy in the pancreas
2.5.8. Autophagy in the lung
2.5.9. Autophagy in innate and adaptive immunity
2.5.10. Pathophysiological Role of Autophagy
2.6. The Role of Autophagy in Kidney Physiology and Physiopathology
2.6.1. Physiology of the Kidney: An Introduction
2.6.2. Autophagy in the Kidney: Health and Disease
II. AIMS of the study
III. Materials and Methods
IV. Results
1. Objective1:Study the functional interaction between autophagy and primary cilium
1.1.Results
1.2. Discussion 1
2. Objective 2: Study the role of autophagy in integration of mechanical stress via primary cilium
2.1. Results
2.2. Discussion 2
V. General Discussion and Perspectives
BIBLIOGRAPHY
