(Downloads - 0)
For more info about our services contact : help@bestpfe.com
Table of contents
I) INTRODUCTION
1) The Liver
1.1) Celullar components
1.2) Mechanisms of liver injury
1.2.1) Apoptosis
1.2.2) Necrosis
1.2.3) Regeneration
1.2.4) Fibrosis
1.2.5) Cirrhosis
2) The Hepatocellular Carcinoma
2.1) Epidemiology
2.2) Risk factors for hepatocellular carcinoma
2.2.1) Hepatitis B virus infection
2.2.2) Hepatitis C virus infection
2.2.3) Alcohol
2.2.4) Aflatoxin
2.2.5) Diabetes, obesity, steatosis and non-alcoholic steatohepatitis
2.2.6) Iron overload diseases
2.3) Molecular mechanisms in the development of hepatocellular carcinoma
2.3.1) Hepatitis B infection
2.3.2) Hepatitis C virus infection
2.3.3) Alcohol
2.3.4) Associated mechanisms NASH, obesity and HCC
2.3.5) Genetic and epigenetic changes in carcinogenesis of HCC
2.4) Preneoplastic lesions
2.4.1) Dysplastic foci: small or large dysplasia
2.4.2) Dysplastic nodules
2.4.3) Regenerative nodules
2.4.4) Iron-free foci
2.4.5) Foci of altered hepatocytes, rich in glycogen / oncocytes
2.4.6) Hepatocellular adenoma
2.5) Histopathology of Hepatocellular carcinoma
2.5.1) Architectural patterns
2.5.2) Cytological variants
2.5.3) Peculiar Histological subtypes
2.6) Molecular classification of hepatocellular carcinoma
2.7) Clinical manifestations
2.7.1) Paraneoplastic Syndromes
2.7.2) Serum AFP
2.8) Treatment
2.8.1) Liver resection
2.8.2) Abaltive treatments
2.8.3) Targeted Therapies
3) The non – cirrhotic hepatocellular carcinoma (NC – HCC)
3.1) Demographic characteristics
3.2) Molecular profile
4) Hepatocellular Carcinoma in Peru
4.1) Possible causes
4.1.1) Infectious
4.1.2) Environmental pollution
II) WORK OBJECTIVES
1) Section 1
1.1) Description of the phenotype of the non-tumor liver of patients with NC- HCC
2) Section 2
2.1) Description of the tumor phenotype of patients with NC-HCC
2.1.1) Material and methods
3) Section 3
3.1) Analyze the relationship between environmental exposure to heavy metals in two cohorts and the clinical manifestations of the disease as well as in survival
III) GENERAL DISCUSSION
IV) PERSPECTIVES
V) REFERENCES
