Other opportunistic moulds: aspergillosis

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Table of contents

Chapter 1. State of the art: fungal infections in individuals living with HIV
a) PCP and the discovery of the HIV/AIDS pandemic
i) “An outbreak of community-acquired Pneumocystis carinii pneumonia: Initial manifestation of cellular immune dysfunction”
ii) PCP: characteristics
iii) PCP: trends over time
b) Other fungal infections in HIV-infected individuals
i) Cryptococcosis
ii) Dimorphic fungi
(1) Histoplasmosis
(2) Coccidioidomycosis
(3) Penicilliosis
(4) Other dimorphic fungi
iii) Other opportunistic moulds: aspergillosis
c) Immunosuppression and fungal risk among individuals living with HIV
i) Immunosuppression among individuals living with HIV
ii) Immune regulation and fungi
(1) CD4+ lymphocyte defects
(2) Other defects
(3) Immunosuppression and invasive aspergillosis
ii) Impact of cART on fungal infections
Chapter 2. Methods
1) The French Hospital DataBase On HIV; ANRS CO4 Cohort
a) Creation of the FHDH – ANRS CO4 cohort (FHDH)
b) Objectives
c) Data collected
d) Published results from FHDH
2) Study of Pneumocystis jirovecii pneumonia (PCP) in the FHDH
a) Definition of cases
b) Selection of patients
3) Study of invasive aspergillosis (IA) in the FHDH
a) Selection of patients
b) Data collection: national retrieval of medical records
c) Validation of IA cases
4) Statistical methods
a) Estimation of prevalence and incidence in the FHDH
i) PCP
ii) Invasive aspergillosis (IA)
b) Survival estimates for PCP and invasive aspergillosis
i) PCP
ii) Invasive aspergillosis
c) Study of risk factors using Cox proportional hazards models
i) PCP
ii) Invasive aspergillosis (IA)
Chapter 3. Trends in PCP among HIV-infected individuals in France in the cART era
Article 1. Critical importance of long-term adherence to care in HIV infected patients in the cART era: new insights from Pneumocystis jirovecii pneumonia cases over 2004-2011 in the FHDH-ANRS CO4 cohort.
Denis B, Guiguet M, de Castro N, Mechaï F, Revest M, Mahamat A, Gregoire GM, Lortholary O, Costagliola D, PLoS One. 2014 Apr 11;9(4):e94183. doi: 10.1371/journal.pone.0094183. eCollection 2014.
Chapter 4. Invasive aspergillosis in HIV-infected individuals and survival trends over a 20-year period in France
Article 2. Relevance of EORTC Criteria for the Diagnosis of Invasive Aspergillosis in HIVInfected Patients, and Survival Trends Over a 20-Year Period in France
Denis B, Guiguet M, de Castro N, Mechaï F, Revest M, Melica G, Costagliola D, Lortholary O; French Hospital Database on HIV Agence Nationale de Recherche sur le SIDA et les hépatites virales, France CO4. Clin Infect Dis. 2015 Oct 15;61(8):1273-80
Chapter 5. Discussion and perspectives
Conclusion
Appendix
Bibliography