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Table of contents
I GENERAL INTRODUCTION
II ORIGINS AND CLINICAL APPLICATIONS OF PHOTODYNAMIC THERAPY
III PHOTOSENSITIZATION MECHANISMS
III.1 Pathways of molecular excitation and deactivation
III.2 Mechanism of photosensitized reactions
III.3 Type I photosensitization processes
III.4 Type II photosensitization processes
III.5 Photosensitisers
III.5 5,10,15,20-meta-tetra(hydroxyphenyl)chlorin
IV PHOTOBLEACHING
IV.1 Photobleaching mechanisms
IV.2 Parameters affecting photobleaching. Aggregation state, pH, ionic strength and oxygen concentration
IV.3 Photoproducts formation
V LIPOSOMES
V.1 Amphiphilic lipids
V.2 Lipid bilayers
V.3 Steric stabilization
VI LIPOSOMES FOR ANTI-CANCER DRUG DELIVERY
VI.1 Liposomes for drug delivery
VI.2 Pharmacokinetics and biodistribution of liposomes and liposomal drugs
VI.3 Accumulation of liposomal drugs in tumors
VI.4 Stability in plasma and storage
VI.5 Bioavailability of encapsulated drug
VI.6 Partitioning of lipophilic and amphiphatic drugs into liposomes
VII LIPOSOMES FOR PHOTODYNAMIC THERAPY
VII.1 Liposomal photosensitizing agents
VII.2 Photophysical properties of liposomal photosensitizing agents
VII.3 Pharmacokinetic of liposomal photosensitizing agents
VII.4 Liposomal formulations of meta(tetrahydroxyphenyl)chlorin
VIII OBJECTIVES
IX RESULTS
IX.1 Unusual photoinduced response of mTHPC liposomal formulation (Foslip)
IX.2 Study of meso-tetra(hydroxyphenil)chlorin (mTHPC) redistribution from lipid vesicles to biological substrates
IX.3 Photodynamic therapy with intratumoral administration of lipid-based mTHPC in a model of breast cancer recurrence
X GENERAL DISCUSSION
X CONCLUSIONS AND PERSPECTIVES
