(Downloads - 0)
For more info about our services contact : help@bestpfe.com
Table of contents
1- The dorsal striatum and the basal ganglia-thalamo-cortical motor circuit
1.1 General organization of the striatum
1.2 Striatal projection neurons and main efferent pathways of the dorsal striatum
1.3 Cortical and thalamic inputs to the dorsal striatum
1.4 Striatal dopamine inputs
2- Neurotransmitter receptors and signaling pathways in the dorsal striatum
2.1 DA receptors
2.2 Glutamate receptors
2.3 cAMP production and actions
2.4 Phosphodiesterases
2.5 DARPP-32
2.6 The ERK Cascade
2.7 Integration of multiple signaling pathways activated by DA, roles of D1R and D2R
2.8 Signaling crosstalk between glutamate and DA
2.9 Adenosine receptors and adenosine signaling in SPNs
2.10 Calcium signaling
3- PD and striatal alterations in the absence of dopamine
3.1 Animal models of PD
3.2 Striatal alterations in PD and dopamine deficiency
3.3 Physiological and signaling alterations in SPNs in the absence of dopamine
4- L-DOPA-induced dyskinesia
4.1 Clinical features
4.2 Model of basal ganglia circuit alterations in the dyskinetic state
4.3 Postsynaptic and presynaptic mechanisms of LIDs
4.4 Changes in structural and synaptic plasticity in LIDs
4.5 Molecular bases of LID
4.6 Role of glutamate transmission in LID
4.7 Role of PDEs
4.8 Role of adenosine in LIDs
5- Introduction to biosensor live imaging
5.1 FRET principles
5.2 An historical perspective on fluorescent probes
5.3 cAMP sensors
5.4 ERK sensors
5.5 Genetically encoded Ca2+ indicators (GECIs)
